Growth control of heterologous tissue culture cells in the congenitally athymic nude mouse.

The hereditarily asplenic-athymic (lasat) mouse as an experimental animal model of lepromatous leprosy: role of the spleen in the formation of lepromatoid lesions.

Lozzio et al,(1,2) reported on the successful transplantation of human myelogenous leukemic cells by the use of the hereditarily asplenic-athymic (Lasat) mouse produced by mating the congenitally asplenic mouse impaired of its antibody production and the hereditarily athymic mouse deficient of its cellular immunity. On the other hand, we(3) reported hereditarily asplenic-athymic mouse by mating...

Growth regulation and suppression of metastasis in the congenitally athymic nude mouse.

Increased tumorigenicity and resistance to antibody lysis of human colon tumor cells xenografted in congenitally athymic mice.

are data to suggest it is immunological. Prehn and Outzen (14) showed that syngeneic tumors of high immunogenicity grew better in irradiated adult or untreated newborn athymic mice than in control adult athymic mice. These authors suggested growth of immunogenic tumors in nude mice may be due to an overloading of a weak immune system. No evidence of immu nological memory to the tumor antigen co...

Relationship of Cell Growth Behavior in Vitro to Tumorigenicity in Athymic Nude Mice1

For both theoretical and practical considerations, it would be useful to understand the relationship between growth behavior of tissue culture cell lines and growth control of normal animal tissues in vivo. A review of pre vious attempts to determine this relationship suggested to us that 1 source of the discrepancies was the assay for tumonigenicity. After prolonged growth in the laboratory, a...

Tumorigenicity of Esophageal Cancer Stem Cells (ECSCs) in nude mouse xenograft model

Background and objectives: Modeling cancer in vivo is a very important tool to investigate cancer pathogenesis and molecular mechanisms involved in cancer progression. Laboratory mice are the most common animal used for rebuilding human cancer in vivo. Cancer stem cells (CSCs) are the main reason of failure in cancer therapy because of tumor relapse and metastasis. Isolation of cancer stem cell...